A typical scenario for blistering involves second-degree burns. A victim's hand contacts a high heat source and the skin becomes very red from the burn. The body's natural defenses send out white blood cells and serum to the burned area in order to begin the healing process. Meanwhile, some of the damaged skin begins to shed dead or infected cells.
Bacteria may also begin to infect the wound and cause the formation of pus. All of these fluids are trapped beneath several layers of skin, and the pressure raises the area over the wound. In this scenario, the good white cells and serum are protecting the damaged skin and attacking the bacteria, but the resulting fluids have nowhere to escape. This is why blisters formed by burns can be so large and painful.
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